研究業績

原著論文

2024年

• "CUG repeat RNA-dependent proteasomal degradation of MBNL1 in a cellular model of myotonic dystrophy type 1"
  Yoshitaka Aoki, Motoaki Yanaizu, Ai Ohki, Kai Nishimiya, Yoshihiro Kino
  Biochemical and Biophysical Research Communications 733, 150729 (2024).

  • DOI: 10.1016/j.bbrc.2024.150729

2023年

• "Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2."
  Motoaki Yanaizu,Haruka Adachi,Makoto Araki,Kenji Kontani,Yoshihiro Kino
  Communications biology 6, 1, 616 (2023).

  • DOI: 10.1038/s42003-023-04998-6
• "Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins."
  Riho Komuro,Yuka Honda,Motoaki Yanaizu,Masami Nagahama,Yoshihiro Kino
  Cells 12, 4, 602 (2023).

  • DOI: 10.3390/cells12040602

2022年

• "Inhibition of BACE1 and amyloid β aggregation by polyketide from Streptomyces sp."
  Masashi Yokoya,Keiyo Nakai,Miki Kawashima,Sanae Kurakado,Natchanun Sirimangkalakitti,Yoshihiro Kino,Takashi Sugita,Shinya Kimura,Masamichi Yamanaka,Naoki Saito
  Chemical biology & drug design 99, 2, 264 (2022).

  • DOI: 10.1111/cbdd.13980

2021年

• "Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom Albatrellus yasudae."
  Youki Masuda,Koji Fujihara,Satoshi Hayashi,Hiroaki Sasaki,Yoshihiro Kino,Hitoshi Kamauchi,Masahiro Noji,Jun-Ichi Satoh,Toshikatsu Takanami,Kaoru Kinoshita,Kiyotaka Koyama
  Journal of natural products 84, 6, 1748 (2021).

  • DOI: 10.1021/acs.jnatprod.0c01329

2020年

• "Reactive astrocytes express Aggregatin (FAM222A) in the brains of Alzheimer's disease and Nasu-Hakola disease."
  Jun-Ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Tsuyoshi Ishida,Yuko Saito
  Intractable & rare diseases research 9, 4, 217 (2020).

  • DOI: 10.5582/irdr.2020.03080
• "CELF2 regulates the species-specific alternative splicing of TREM2."
  Motoaki Yanaizu,Chika Washizu,Nobuyuki Nukina,Jun-Ichi Satoh,Yoshihiro Kino
  Scientific reports 10, 1, 17995 (2020).

  • DOI: 10.1038/s41598-020-75057-x
• "FACS-array-based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model."
  Haruko Miyazaki,Tomoyuki Yamanaka,Fumitaka Oyama,Yoshihiro Kino,Masaru Kurosawa,Mizuki Yamada-Kurosawa,Risa Yamano,Tomomi Shimogori,Nobutaka Hattori,Nobuyuki Nukina
  The Journal of biological chemistry 295, 29, 9768 (2020).

  • DOI: 10.1074/jbc.RA120.012983
• "Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity."
  Megumi Akiba,Kaoru Kinoshita,Yoshihiro Kino,Jun-Ichi Sato,Kiyotaka Koyama
  Bioorganic & medicinal chemistry letters 30, 2, 126808 (2020).

  • DOI: 10.1016/j.bmcl.2019.126808

2019年

• "Microglia express TMEM119 in the brains of Nasu-Hakola disease."
  Jun-Ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Tsuyoshi Ishida,Yuko Saito
  Intractable & rare diseases research 8, 4, 260 (2019).

  • DOI: 10.5582/irdr.2019.01123
• "Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease."
  Jun Sone,Satomi Mitsuhashi,Atsushi Fujita,Takeshi Mizuguchi,Kohei Hamanaka,Keiko Mori,Haruki Koike,Akihiro Hashiguchi,Hiroshi Takashima,Hiroshi Sugiyama,Yutaka Kohno,Yoshihisa Takiyama,Kengo Maeda,Hiroshi Doi,Shigeru Koyano,Hideyuki Takeuchi,Michi Kawamoto,Nobuo Kohara,Tetsuo Ando,Toshiaki Ieda,Yasushi Kita,Norito Kokubun,Yoshio Tsuboi,Kazutaka Katoh,Yoshihiro Kino,Masahisa Katsuno,Yasushi Iwasaki,Mari Yoshida,Fumiaki Tanaka,Ikuo K Suzuki,Martin C Frith,Naomichi Matsumoto,Gen Sobue
  Nature genetics 51, 8, 1215 (2019).

  • DOI: 10.1038/s41588-019-0459-y
• "Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of Boletinus asiaticus."
  Genki Yatsu,Yoshihiro Kino,Hiroaki Sasaki,Jun-Ichi Satoh,Kaoru Kinoshita,Kiyotaka Koyama
  Journal of natural products 82, 7, 1797 (2019).

  • DOI: 10.1021/acs.jnatprod.8b01092
• "Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease."
  Satoh JI,Kino Y,Yanaizu M,Ishida T,Saito Y
  Intractable & rare diseases research 8, 2, 120 (2019).

  • DOI: 10.5582/irdr.2019.01049
• "Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads."
  Mitsuhashi S,Frith MC,Mizuguchi T,Miyatake S,Toyota T,Adachi H,Oma Y,Kino Y,Mitsuhashi H,Matsumoto N
  Genome biology 20, 1, 58 (2019).

  • DOI: 10.1186/s13059-019-1667-6

2018年

• "Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-Transcriptional regulation"
  Motoaki Yanaizu,Kenji Sakai,Youhei Tosaki,Yoshihiro Kino,Jun-Ichi Satoh
  Scientific Reports 8, 1, 6937 (2018).

  • DOI: 10.1038/s41598-018-25204-2
• "Microglia express gamma-interferon-inducible lysosomal thiol reductase in the brains of Alzheimer's disease and Nasu-Hakola disease."
  Satoh JI,Kino Y,Yanaizu M,Ishida T,Saito Y
  Intractable & rare diseases research 7, 4, 251 (2018).

  • DOI: 10.5582/irdr.2018.01119
• "Alzheimer's disease pathology in Nasu-Hakola disease brains"
  Jun-Ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Yuko Saito
  Intractable and Rare Diseases Research 7, 1, 32 (2018).

  • DOI: 10.5582/irdr.2017.01088

2017年

• "Gastric and intestinal proteases resistance of chicken acidic chitinase nominates chitin-containing organisms for alternative whole edible diets for poultry"
  Eri Tabata,Akinori Kashimura,Satoshi Wakita,Misa Ohno,Masayoshi Sakaguchi,Yasusato Sugahara,Yoshihiro Kino,Vaclav Matoska,Peter O. Bauer,Fumitaka Oyama
  SCIENTIFIC REPORTS 7, 1, 6662 (2017).

  • DOI: 10.1038/s41598-017-07146-3
• "Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains"
  Jun-Ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Youhei Tosaki,Kenji Sakai,Tusyoshi Ishida,Yuko Saito
  Intractable and Rare Diseases Research 6, 1, 50 (2017).

  • DOI: 10.5582/irdr.2016.01097
• "Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease"
  Jun-Ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Youhei Tosaki,Kenji Sakai,Tsuyoshi Ishida,Yuko Saito
  Intractable and Rare Diseases Research 6, 4, 262 (2017).

  • DOI: 10.5582/irdr.2017.01073

2016年

• "RNA sequencing data analysis identifies a difference in gene expression profile between microglia and astrocytes after lipopolysaccharide-induced neuroinflammation"
  Jun-Ichi Satoh,Youhei Tosaki,Kenji Sakai,Motoaki Yanaizu,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 8, 1, 60 (2016).

  • DOI: 10.1111/cen3.12351
• "Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs"
  Kazuaki Okawa,Misa Ohno,Akinori Kashimura,Masahiro Kimura,Yuki Kobayashi,Masayoshi Sakaguchi,Yasusato Sugahara,Minori Kamaya,Yoshihiro Kino,Peter O. Bauer,Fumitaka Oyama
  MOLECULAR BIOLOGY AND EVOLUTION 33, 12, 3183 (2016).

  • DOI: 10.1093/molbev/msw198
• "P2Y12 expression on microglia in the human brain"
  Jun-Ichi Satoh,Youhei Tosaki,Kenji Sakai,Motoaki Yanaizu,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 7, 4, 366 (2016).

  • DOI: 10.1111/cen3.12320
• "Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy"
  Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, Duboc D, Wahbi K, Matsumura T, Fujimura H, Mochizuki H, Deryckere F, Kimura T, Nukina N, Ishiura S, Lacroix V, Campan-Fournier A, Navratil V, Chautard E, Auboeuf D, Horie M, Imoto K, Lee KY, Swanson MS, Lopez de Munain A, Inada S, Itoh H, Nakazawa K, Ashihara T, Wang E, Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N.
  NATURE COMMUNICATIONS 7, 11067 (2016).

  • DOI: 10.1038/ncomms11067
• "TMEM119 marks a subset of microglia in the human brain"
  Jun-ichi Satoh,Yoshihiro Kino,Naohiro Asahina,Mika Takitani,Junko Miyoshi,Tsuyoshi Ishida,Yuko Saito
  NEUROPATHOLOGY 36, 1, 39 (2016).

  • DOI: 10.1111/neup.12235
• "Targeted sequencing approach to identify genetic mutations in nasu-hakola disease"
  Jun-ichi Satoh,Motoaki Yanaizu,Youhei Tosaki,Kenji Sakai,Yoshihiro Kino
  Intractable and Rare Diseases Research 5, 4, 269 (2016).

  • DOI: 10.5582/irdr.2016.01064
• "Expression of gp91phox and p22phox, catalytic subunits of nadph oxidase, on microglia in nasu-hakola disease brains"
  Jun-ichi Satoh,Yoshihiro Kino,Motoaki Yanaizu,Youhei Tosaki,Kenji Sakai,Tusyoshi Ishida,Yuko Saito
  Intractable and Rare Diseases Research 5, 4, 275 (2016).

  • DOI: 10.5582/irdr.2016.01086

2015年

• "FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice"
  Yoshihiro Kino,Chika Washizu,Masaru Kurosawa,Mizuki Yamada,Hiroshi Doi,Toru Takumi,Hiroaki Adachi,Masahisa Katsuno,Gen Sobue,Geoffrey G. Hicks,Nobutaka Hattori,Tomomi Shimogori,Nobuyuki Nukina
  SCIENTIFIC REPORTS 6, 35236 (2015).

  • DOI: 10.1038/srep35236
• "RNA-Seq data mining approach identifies opalin as a reliable marker for myelinating oligodendrocytes"
  Jun-Ichi Satoh,Mika Takitani,Junko Miyoshi,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 7, 1, 66 (2015).

  • DOI: 10.1111/cen3.12240
• "RNA-Seq data analysis identifies the comprehensive profile of in vivo interferon-β-stimulated genes in multiple sclerosis"
  Jun-Ichi Satoh,Mika Takitani,Junko Miyoshi,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 7, 1, 39 (2015).

  • DOI: 10.1111/cen3.12268
• "Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains"
  Jun-ichi Satoh,Yoshihiro Kino,Nobutaka Motohashi,Tsuyoshi Ishida,Saburo Yagishita,Kenji Jinnai,Nobutaka Arai,Kiyotaka Nakamagoe,Akira Tamaoka,Yuko Saito,Kunimasa Arima
  NEUROPATHOLOGY 35, 6, 529 (2015).

  • DOI: 10.1111/neup.12222
• "Legumain is expressed on macrophages in active demyelinating lesions of multiple sclerosis"
  Jun-Ichi Satoh,Naohiro Asahina,Shouta Kitano,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 6, 3, 304 (2015).

  • DOI: 10.1111/cen3.12208
• "Expression profiles of RNA-Seq-based grey matter-specific genes versus white matter-specific genes in grey matter lesions of multiple sclerosis"
  Jun-Ichi Satoh,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 6, 3, 289 (2015).

  • DOI: 10.1111/cen3.12218
• "Bioinformatics data mining approach indicates the expression of chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq)-based hypoxia-inducible factor-1α target genes in periplaque lesions of multiple sclerosis"
  Jun-Ichi Satoh,Naohiro Asahina,Shouta Kitano,Yoshihiro Kino
  Clinical and Experimental Neuroimmunology 6, 2, 159 (2015).

  • DOI: 10.1111/cen3.12195
• "MicroRNA-seq data analysis pipeline to identify blood biomarkers for Alzheimer’s disease from public data"
  Jun-Ichi Satoh,Yoshihiro Kino,Shumpei Niida
  Biomarker Insights 10, 21 (2015).

  • DOI: 10.4137/BMIMI.S25132
• "FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis"
  Yoshihiro Kino,Chika Washizu,Masaru Kurosawa,Mizuki Yamada,Haruko Miyazaki,Takumi Akagi,Tsutomu Hashikawa,Hiroshi Doi,Toru Takumi,Geoffrey G. Hicks,Nobutaka Hattori,Tomomi Shimogori,Nobuyuki Nukina
  ACTA NEUROPATHOLOGICA COMMUNICATIONS 3, 24 (2015).

  • DOI: 10.1186/s40478-015-0202-6
• "Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice"
  Masaru Kurosawa,Gen Matsumoto,Yoshihiro Kino,Misako Okuno,Mizuki Kurosawa-Yamada,Chika Washizu,Harumi Taniguchi,Kazuhiro Nakaso,Toru Yanagawa,Eiji Warabi,Tomomi Shimogori,Takashi Sakurai,Nobutaka Hattori,Nobuyuki Nukina
  HUMAN MOLECULAR GENETICS 24, 4, 1092 (2015).

  • DOI: 10.1093/hmg/ddu522
• "Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins"
  Yoshihiro Kino,Chika Washizu,Masaru Kurosawa,Yoko Oma,Nobutaka Hattori,Shoichi Ishiura,Nobuyuki Nukina
  HUMAN MOLECULAR GENETICS 24, 3, 740 (2015).

  • DOI: 10.1093/hmg/ddu492
• "Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72."
  Kitano S,Kino Y,Yamamoto Y,Takitani M,Miyoshi J,Ishida T,Saito Y,Arima K,Satoh J
  Journal of Central Nervous System Disease 7, 15 (2015).
• "A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis."
  Satoh J,Asahina N,Kitano S,Kino Y
  Journal of central nervous system disease 7, 1 (2015).

  • DOI: 10.4137/JCNSD.S23210

2014年

• "A comprehensive profile of ChIp-Seq-Based PU.1/Spi1 target genes in microglia"
  Jun-Ichi Satoh,Naohiro Asahina,Shouta Kitano,Yoshihiro Kino
  Gene Regulation and Systems Biology 8, 127 (2014).

  • DOI: 10.4137/GRSB.S19711
• "Singular localization of sodium channel beta 4 subunit in unmyelinated fibres and its role in the striatum"
  Haruko Miyazaki,Fumitaka Oyama,Ritsuko Inoue,Toshihiko Aosaki,Takaya Abe,Hiroshi Kiyonari,Yoshihiro Kino,Masaru Kurosawa,Jun Shimizu,Ikuo Ogiwara,Kazuhiro Yamakawa,Yoshinori Koshimizu,Fumino Fujiyama,Takeshi Kaneko,Hideaki Shimizu,Katsuhiro Nagatomo,Katsuya Yamada,Tomomi Shimogori,Nobutaka Hattori,Masami Miura,Nobuyuki Nukina]
  NATURE COMMUNICATIONS 5, 5525 (2014).

  • DOI: 10.1038/ncomms6525
• "LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains"
  Jun-ichi Satoh,Nobutaka Motohashi,Yoshihiro Kino,Tsuyoshi Ishida,Saburo Yagishita,Kenji Jinnai,Nobutaka Arai,Kiyotaka Nakamagoe,Akira Tamaoka,Yuko Saito,Kunimasa Arima
  ORPHANET JOURNAL OF RARE DISEASES 9, 68 (2014).

  • DOI: 10.1186/1750-1172-9-68
• "Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntingtons disease"
  Megha Maheshwari,Supriya Bhutani,Aniruddha Das,Rajarshi Mukherjee,Ankit Sharma,Yoshihiro Kino,Nobuyuki Nukina,Nihar Ranjan Jana
  HUMAN MOLECULAR GENETICS 23, 10, 2737 (2014).

  • DOI: 10.1093/hmg/ddt667
• "Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2"
  Akiko Asada,Rena Yamazaki,Yoshihiro Kino,Taro Saito,Taeko Kimura,Mao Miyake,Masato Hasegawa,Nobuyuki Nukina,Shin-ichi Hisanaga
  NEUROSCIENCE LETTERS 563, 112 (2014).

  • DOI: 10.1016/j.neulet.2014.01.046
• "Molecular network analysis suggests a logical hypothesis for the pathological role of c9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia."
  Satoh J,Yamamoto Y,Kitano S,Takitani M,Asahina N,Kino Y
  Journal of central nervous system disease 6, 69 (2014).

  • DOI: 10.4137/JCNSD.S18103
• "PLD3 is accumulated on neuritic plaques in Alzheimer's disease brains"
  Jun-ichi Satoh,Yoshihiro Kino,Yoji Yamamoto,Natsuki Kawana,Tsuyoshi Ishida,Yuko Saito,Kunimasa Arima
  ALZHEIMERS RESEARCH & THERAPY 6, 9, 70 (2014).

  • DOI: 10.1186/s13195-014-0070-5
• "RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer's Disease Brains"
  Jun-ichi Satoh,Yoji Yamamoto,Naohiro Asahina,Shouta Kitano,Yoshihiro Kino
  DISEASE MARKERS 2014, 123165 (2014).

  • DOI: 10.1155/2014/123165
• "Molecular network analysis suggests a logical hypothesis for the pathological role of c9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia."
  Satoh J,Yamamoto Y,Kitano S,Takitani M,Asahina N,Kino Y
  Journal of Central Nervous System Disease 6, 69 (2014).

  • DOI: 10.4137/JCNSD.S24317
• "TMEM106B expression is reduced in Alzheimer's disease brains"
  Jun-ichi Satoh,Yoshihiro Kino,Natsuki Kawana,Yoji Yamamoto,Tsuyoshi Ishida,Yuko Saito,Kunimasa Arima
  ALZHEIMERS RESEARCH & THERAPY 6, 2, 17 (2014).

  • DOI: 10.1186/alzrt247